PPO-allene

• Description :

  PPO-allene is a covalent botulinum neurotoxin (BoNT) light chain inhibitor (IC50: 20.9 μM) . PPO-allene (0.3 mg/kg, i.v.) demonstrates an in vivo half-life of approximately 1.5 h in mice[1].

• UNSPSC :

  12352005

• Target :

  Bacterial

• Related Pathways :

  Anti-infection

• Field of Research :

  Neurological Disease

• Smiles :

  O=C1C=C(N=C2C(O)=C(C=CN21)CCCNC(C=C=C)=O)CNCC3=CC=C(C=C3)C4=CC=CC=C4

• Molecular Formula :

  C29H28N4O3

• Molecular Weight :

  480.56

• References & Citations :

  [1]Lin M, et al. Bifunctional Inhibition of Botulinum Neurotoxin A Protease: Unexpected Active Site Inhibition Enhances Covalent Targeting of an Allosteric Site. J Med Chem. 2025 Apr 24;68 (8) :8796-8816.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported