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X15695

CAT: 0804-HY-175785-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-175785-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
X15695 is selective and orally active estrogen receptor (ERα) degrader. X15695 is an aryl hydrocarbon receptor (AHR) ligand. X15695 enables AHR to form a complex with the ERα, promoting its proteasomal degradation. X15695 inhibits the breast cancer cells proliferation, promotes cell cycle block and induces apoptosis. X15695 can be used for the study of breast cancer[1][2].
CAS Number
353258-25-0
UNSPSC
12352005
Target
Apoptosis; Aryl Hydrocarbon Receptor; Estrogen Receptor/ERR; MDM-2/p53
Related Pathways
Apoptosis; Immunology/Inflammation; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.45
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(C1=CN2C(C(Cl)=C1)=NC(C3=CC=C(F)C=C3)=C2)(F)F
Molecular Formula
C14H7ClF4N2
Molecular Weight
314.67
References & Citations
[1]Katrin Koellisch, et al. Distinct 2-phenyl-imidazo[1, 2α] pyridine derivatives drive ER degradation and selectively impair proliferation of ER breast cancer cells via the aryl hydrocarbon receptor+. 2025 Aug 1|[2]Pan M, et al. Identification of an Imidazopyridine-based Compound as an Oral Selective Estrogen Receptor Degrader for Breast Cancer Therapy. Cancer Res Commun. 2023 Jul 27;3 (7) :1378-1396.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERα

Alternative Products

CatalogName
GTR19273192-01X15695

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