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Antiparasitic agent-28

CAT: 0804-HY-175648Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175648Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Antiparasitic agent-28 is an orally active, selective inhibitor of Toxoplasma gondii phenylalanine tRNA synthetase (TgcPheRS) with blood-brain barrier penetration. Antiparasitic agent-28 inhibits the growth of T. gondii tachyzoites (TgME49-Fluc strain) an (EC50 = 1 nM) and T. gondii bradyzoites (Tg68nLuc strain) induced by alkaline (EC50 = 3 nM) and glutamine-rich medium (EC50 = 0.1 nM) . Antiparasitic agent-28 demonstrates potent anti-toxoplasmosis efficacy in mice infected with TgME49-Fluc tachyzoites. Antiparasitic agent-28 can be used for the study of Toxoplasma gondii infection[1].
UNSPSC
12352100
Target
Parasite
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C(N1C[C@]([C@@H](C2=CC=C(C#CC3=CC=CC=C3O)C=C2)CC4)([H])N4CCC1)NC5=CC=C(OC)C=C5
Molecular Formula
C30H31N3O3
Molecular Weight
481.59
References & Citations
[1]Uddin T, et al. Improved Bicyclic Pyrrolidine Analogues Inhibit Toxoplasma gondii Growth In Vitro and Cure Infection In Vivo. J Med Chem. 2025 Aug 28;68 (16) :17350-17363.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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