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CHIPOpt

CAT: 0804-HY-175552Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175552Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CHIPOpt, a peptide, is an orthosteric CHIP TPR domain inhibitor with a Kd of ∼16 nM. CHIPOpt has anti-aggregation activity and decreases p.tau ubiquitination with little effect on unmodified tau. CHIPOpt can be used for Alzheimer’s disease research[1].
UNSPSC
12352209
Target
Tau Protein
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(C)N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(O)=O)CC(O)=O)=O)CCC1)=O)CC2=CNC3=CC=CC=C23)=O)CC4=CNC5=CC=CC=C45)=O)CC(C)C
Molecular Formula
C39H47N7O9
Molecular Weight
757.83
References & Citations
[1]Nadel CM, et al. The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT) . J Mol Biol. 2023 Jun 1;435 (11) :168026.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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