CHIPOpt

• Description :

  CHIPOpt, a peptide, is an orthosteric CHIP TPR domain inhibitor with a Kd of ∼16 nM. CHIPOpt has anti-aggregation activity and decreases p.tau ubiquitination with little effect on unmodified tau. CHIPOpt can be used for Alzheimer’s disease research[1].

• UNSPSC :

  12352209

• Target :

  Tau Protein

• Related Pathways :

  Neuronal Signaling

• Field of Research :

  Neurological Disease

• Smiles :

  O=C(C)N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(O)=O)CC(O)=O)=O)CCC1)=O)CC2=CNC3=CC=CC=C23)=O)CC4=CNC5=CC=CC=C45)=O)CC(C)C

• Molecular Formula :

  C39H47N7O9

• Molecular Weight :

  757.83

• References & Citations :

  [1]Nadel CM, et al. The E3 Ubiquitin Ligase, CHIP/STUB1, Inhibits Aggregation of Phosphorylated Proteoforms of Microtubule-associated Protein Tau (MAPT) . J Mol Biol. 2023 Jun 1;435 (11) :168026.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported