OLIG2-IN-1

CAT: 0804-HY-175530Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175530Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
OLIG2-IN-1 is a potent and selective oligodendrocyte transcription factor 2 (OLIG2) inhibitor. OLIG2-IN-1 directly and dose-dependently downregulates nuclear OLIG2 levels with an IC50 value of 0.88 μM. OLIG2-IN-1 exhibits strong anti-proliferative activity in U87 and U251 cells with IC50 values of 7.02 μM and 6.43 μM, respectively. OLIG2-IN-1 can be used for the research of cancer, such as glioblastoma multiforme[1].
UNSPSC
12352005
Target
OLIG2
Related Pathways
Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
NC1=NC=NC(NC(NC2=CC(Cl)=C(Cl)C=C2)=O)=C1
Molecular Formula
C11H9Cl2N5O
Molecular Weight
298.13
References & Citations
[1]Xu Z, et al. Discovery of novel pyrimidine-4,6-diamine-based OLIG2 inhibitors as potent anti-glioblastoma agents. Eur J Med Chem. 2025 Nov 15;298:118009.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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