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UNC9750

CAT: 0804-HY-175477Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175477Size:1 Each
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Description
UNC9750 is an inositol phosphate multikinase (IPMK) inhibitor with IC50 values ​​of 31.6 and 374 nM for IPMK and IP6K2, respectively.. UNC9750 inhibits cellular accumulation of InsP5, the direct product of IPMK kinase activity, while having no effect on either InsP6 or InsP7 levels. UNC9750 has ≥ 75% inhibition of four kinases (DAPK1, DYRK1B, PDGFR, and KDR) . UNC9750 can be used for the study of glioblastoma[1].
CAS Number
[2967648-29-7]
UNSPSC
12352005
Target
DAPK; DYRK; IPK Superfamily; PDGFR
Related Pathways
Apoptosis; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
C1(C2=NN=NN2)=CC3=C(ON=C3C=C1)C4=CC(C5CCN(CC5)C6CCC6)=CC=C4
Molecular Formula
C23H24N6O
Molecular Weight
400.48
References & Citations
[1]Zhou Y, et al. Design, Synthesis, and Cellular Characterization of a New Class of IPMK Kinase Inhibitors. J Med Chem. 2025 Aug 14;68 (15) :15446-15460.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DAPK1; DYRK1; PDGFR

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