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N3-CMC

CAT: 0804-HY-175424Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175424Size:1 Each
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Description
N3-CMC is a click chemistry reagent. N3-CMC containing an azide group can undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. N3-CMC can also undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. N3-CMC reacts specifically with the pseudouridine (Ψ) -containing RNA, and biotin is subsequently conjugated to the N3-CMC-Ψ RNA via click chemistry, quantitatively analyzing the dynamic changes of Ψ[1].
CAS Number
1801187-61-0
UNSPSC
12352005
Target
Others
Related Pathways
Others
Field of Research
Others
Smiles
C[N+]1(CCN=[C@@]=N[C@H]2CC[C@@H](N=[N+]=[N-])CC2)CCOCC1.O=S(C3=CC=C(C)C=C3)([O-])=O
Molecular Formula
C21H32N6O4S
Molecular Weight
464.58
References & Citations
[1]Li X, et al. Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome. Nat Chem Biol. 2015 Aug;11 (8) :592-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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