N3-CMC

• Description:

  N3-CMC is a click chemistry reagent. N3-CMC containing an azide group can undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups. N3-CMC can also undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. N3-CMC reacts specifically with the pseudouridine (Ψ) -containing RNA, and biotin is subsequently conjugated to the N3-CMC-Ψ RNA via click chemistry, quantitatively analyzing the dynamic changes of Ψ[1].

• UNSPSC:

  12352005

• Target:

  Others

• Related Pathways:

  Others

• Field of Research:

  Others

• Smiles:

  C[N+]1 (CCN=[C@@]=N[C@H]2CC[C@@H] (N=[N+]=[N-]) CC2) CCOCC1.O=S (C3=CC=C (C) C=C3) ([O-]) =O

• Molecular Formula:

  C21H32N6O4S

• Molecular Weight:

  464.58

• References & Citations:

  [1]Li X, et al. Chemical pulldown reveals dynamic pseudouridylation of the mammalian transcriptome. Nat Chem Biol. 2015 Aug;11 (8) :592-7.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1801187-61-0