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Selinexor-d5

CAT: 0804-HY-17536SSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-17536SSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Selinexor-d5 (KPT-330-d5) isthe deuterium labeled Selinexor. Selinexor (KPT-330), an analog of KPT-185, is an orally active and selective CRM1 inhibitor[1][2].
Product Name Alternative
KPT-330-d5
UNSPSC
12352005
Target
CRM1; Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Others
Field of Research
Cancer
Smiles
O=C(NNC1=NC([2H])=C([2H])N=C1[2H])/C([2H])=C([2H])\N2N=C(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)N=C2
Molecular Formula
C17H6D5F6N7O
Molecular Weight
448.34
References & Citations
[1]Etchin J, et al. KPT-330 inhibitor of CRM1 (XPO1) -mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia. Br J Haematol. 2013 Apr;161 (1) :117-27. |[2]Tai YT, et al. CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications. Leukemia. 2014 Jan;28 (1) :155-65.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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