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DHI1

CAT: 0804-HY-175261Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175261Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DHI1 is an anti-leukemia agent with high selectivity for Jurkat (IC50 = 21.83 μM) and HL-60 (IC50 = 19.14 μM) leukemia cells and has low toxicity to non-cancerous cells. DHI1 can induce G2/M phase cell arrest in Jurkat and HL-60 leukemia cells, as well as S phase arrest in HL-60 cells, and has significant effects on cell cycle signaling molecules Wee1, cyclin B1, cdc2 on Tyr15, and Chk1. DHI1 inhibits the migration and invasion of Jurkat and HL-60 cells by disrupting cytoskeletal actin filaments. DHI1 can be used to study hematological malignancies[1].
UNSPSC
12352005
Target
CDK; Checkpoint Kinase (Chk) ; Wee1
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
CN1C=C(C2=CC=CC=C21)C3CC(C4=CC=C(Br)C=C4)=NO3
Molecular Formula
C18H15BrN2O
Molecular Weight
355.23
References & Citations
[1]Monika Majirská, et al. Discovery of Anticancer Indole-Based 4,5-Dihydroisoxazole Derivative with Selectivity toward Leukemia Cells. ACS Pharmacology & Translational Science Article ASAP.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Chk1

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