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ST171

CAT: 0804-HY-175231-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-175231-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ST171 is a bitopic 5-HT1AR agonist with an Ki of 0.41 nM. ST171 selectively activates Gi/o signaling pathway and inhibits 5-HT1AR-mediated cAMP accumulation without Gs activation and marginal β-arrestin recruitment. T171 reduces hypersensitivity in chronic neuropathic and inflammatory pain mice model. ST171 can be used for pain research[1].
UNSPSC
12352005
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Purity
99.30
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
COC1=CC=CC=C1OCCNCCCOC2=CC=C3OCC(NC3=C2)=O
Molecular Formula
C20H24N2O5
Molecular Weight
372.41
References & Citations
[1]Ullrich A, et al. Discovery of a functionally selective serotonin receptor (5-HT1AR) agonist for the treatment of pain. Sci Adv. 2025 Jun 20;11 (25) :eadv9267.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor

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