FHND5032

CAT: 0804-HY-174976-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-174976-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

FHND5032 is an orally active miR-124 inducer. FHND5032 significantly upregulates miR-124 expression in macrophages. FHND5032 disrupts inflammatory signaling, promotes macrophage reprogramming, and restores the epithelial barrier function by inhibiting the PIK3R2/PI3K/Akt axis. FHND5032 alleviates colitis and reduces inflammatory burden in ulcerative colitis mice. FHND5032 can be used for the study of ulcerative colitis[1].

CAS Number

3076057-63-8

UNSPSC

12352005

Target

Akt; Bacterial; Interleukin Related; PI3K

Related Pathways

Anti-infection; Immunology/Inflammation; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Concentration

10mM

Purity

99.49

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

FC(F)(OC1=CC=C(C=C1)NC2=NC3=CC(Cl)=CC=C3C=N2)F

Molecular Formula

C15H9ClF3N3O

Molecular Weight

339.70

References & Citations

[1]Wang T, et al. Novel Small-Molecule miR-124 Inducer Acts as "a Physiological Brake" of Inflammation in Ulcerative Colitis by Targeting the PIK3R2/PI3K/Akt Axis. J Med Chem. 2025 Jul 10;68 (13) :14114-14126.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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