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AZ12943203

CAT: 0804-HY-174923Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174923Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZ12943203 (Compound 13e) is a GSK-3 PET radioligand with a Kd of 2.94 nM. AZ12943203 has a significant inhibitory potency toward GSK-3β (IC50 : 4.44 nM), and can specifically bind to GSK-3-rich regions of the rodent brain. AZ12943203 can be used for neurodegenerative diseases imaging, particularly Alzheimer’s disease[1].
UNSPSC
12352005
Target
Biochemical Assay Reagents; GSK-3
Related Pathways
Others; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
CC(N1CCN(CC2=CC=C(NC3=NC=C(F)C(C4=CN=C(C)N4C5CCOCC5)=N3)C=C2)CC1)=O
Molecular Formula
C26H32FN7O2
Molecular Weight
493.58
References & Citations
[1]Li Y, et al. Radiosynthesis and Evaluation of 11C-Labeled Imidazolyl Pyrimidine Derivatives for Positron Emission Tomography Imaging of Glycogen Synthase Kinase-3[J]. ACS Pharmacology & Translational Science, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T210726-01AZ12943203

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