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PZ671

CAT: 0804-HY-174876Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174876Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PZ671 is a potent Bcl-xL PROTAC degrader with an IC50 of 1.3 nM (MOLT-4 cells) and a DC50 of 0.9 nM (Bcl-xL). PZ671 induces apoptosis in MOLT-4 cells. PZ671 effectively inhibits tumor growth and rapidly reverses transient platelet counts reduction in MOLT-4 xenograft mice. PZ671 can be used for the research of cancer, such as small cell lung cancer (SCLC). (Structure Note: Pink: Bcl-xL ligand ; Blue: CRBN Ligand (HY-138793) ; Black: linker; E3-linker (HY-174879) )
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; PROTACs
Related Pathways
Apoptosis; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(NS(=O)(C1=CC=C(N[C@@H](CSC2=CC=CC=C2)CCN(C)CCOCCOCCOCCCC3=CC4=C(C(N(C(CC5)C(NC5=O)=O)C4)=O)C=C3)C(S(=O)(C(F)(F)F)=O)=C1)=O)C6=CC=C(N7CCN(CC8=C(C9=CC=C(Cl)C=C9)CCC(C)(C)C8)CC7)C=C6
Molecular Formula
C66H79ClF3N7O11S3
Molecular Weight
1335.02
References & Citations
[1]Zhang P, et al. Discovery of PZ671, a highly potent and in vivo active CRBN-recruiting Bcl-xL degrader. RSC Med Chem. 2025 May 23.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcl-xL; Cereblon

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CatalogName
GTR19263914-01PZ671

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