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POLRMT-IN-2

CAT: 0804-HY-174827Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-174827Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
POLRMT-IN-2 is a potent POLRMT inhibitor. POLRMT-IN-2 exhibits strong antiproliferative activity in MOLM-13 cells, with an IC50 of 1.01 μM. POLRMT-IN-2 disrupts mitochondrial function and induces apoptosis in MOLM-13cells. POLRMT-IN-2 can be used for the study of acute myeloid leukemia (AML) [1].
UNSPSC
12352005
Target
Apoptosis; Mitochondrial Metabolism; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
CC1=CC=C(C(C)=C1)C2=CC(OC3=C2C=CC(O[C@@H](C(N4C5CN(C(NC6=CC=CC(C#N)=C6)=O)CC4CC5)=O)C)=C3)=O
Molecular Formula
C34H32N4O5
Molecular Weight
576.64
References & Citations
[1]Liu T, Cheng X, Wang Y, Hao W, Wang H, Zhang K, Wang J. Design, Synthesis and Biological Evaluation of POLRMT Inhibitors for the Treatment of Acute Myeloid Leukemia. Chem Biol Drug Des. 2025 May;105 (5) :e70127.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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