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VU439

CAT: 0804-HY-174821Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174821Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VU439 is a functionalized photoaffinity ligand of Elexacaftor. VU439 retains the activity of Elexacaftor as a CFTR corrector and can identify SCCPDH as a specific off-target of Elexacaftor through chemoproteomics[1].
UNSPSC
12352005
Target
CFTR
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Others
Smiles
C#CCCC1(N=N1)CCN2N=C(C)C(S(=O)(NC(C3=CC=C(N4C=CC(OCC(C)(C(F)(F)F)C)=N4)N=C3N5C[C@@H](C)CC5(C)C)=O)=O)=C2
Molecular Formula
C32H40F3N9O4S
Molecular Weight
703.78
References & Citations
[1]Kim M, et al. Photoaffinity Ligand of Cystic Fibrosis Corrector VX-445 Identifies SCCPDH as an Off-Target. ACS Chem Biol. 2025 Jun 20.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
GTR19263189-01VU439

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