Gimeracil (Standard)

CAT: 0804-HY-17469R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-17469R-01Size:5 mg
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Description
Gimeracil (Standard) is the analytical standard of Gimeracil. This product is intended for research and analytical applications. Gimeracil, a component of an oral fluoropyrimidine derivative S-1, inhibits DNA DSB repair and is a potent inhibitor of DPYD (dihydropyrimidine dehydrogenase, DPD) [1][2].
CAS Number
[103766-25-2]
UNSPSC
12352100
Target
Dihydropyrimidine Dehydrogenase (DPD) ; DNA/RNA Synthesis; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
O=C1C=C(O)C(Cl)=CN1
Molecular Formula
C5H4ClNO2
Molecular Weight
145.54
References & Citations
[1]Masaru Takagi, et al. Gimeracil sensitizes cells to radiation via inhibition of homologous recombination. Radiother Oncol. 2010 Aug;96 (2) :259-66.|[2]Koh-Ichi Sakata, et al. Gimeracil, an inhibitor of dihydropyrimidine dehydrogenase, inhibits the early step in homologous recombination. Cancer Sci. 2011 Sep;102 (9) :1712-6.|[3]Masakazu Fukushima, et al. Gimeracil, a component of S-1, may enhance the antitumor activity of X-ray irradiation in human cancer xenograft models in vivo. Oncol Rep. 2010 Nov;24 (5) :1307-13.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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