Thalidomide-NH-alkynes

• Description:

  Thalidomide-NH-alkynes is a synthesized E3 ligase ligand-linker conjugate that can be used for synthesis of PROTAC HDAC degrader-2 (HY-174444) [1].

• UNSPSC:

  12352005

• Target:

  E3 Ligase Ligand-Linker Conjugates

• Related Pathways:

  PROTAC

• Field of Research:

  Cancer

• Smiles:

  C#CCCCCOC(CNC1=C2C(N(C(C2=CC=C1)=O)C3CCC(NC3=O)=O)=O)=O

• Molecular Formula:

  C21H21N3O6

• Molecular Weight:

  411.41

• References & Citations:

  [1]Zhai S, et al. Development and Characterization of the First Selective Class IIb Histone Deacetylase Degraders. J Med Chem. 2025 Jul 10;68 (13) :13793-13821.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported