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PCR8

CAT: 0804-HY-174460Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174460Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PCR8 is a prodrug of CR8. pCR8 is amphiphilic and can self-assemble into nanoparticles. pCR8 can release CR8 under the action of high concentration of H2O2 in the tumor microenvironment. CR8 is a molecular glue degrader that can effectively degrade cell cycle-related proteins and has antitumor activity. pCR8 can be used in the research of tumors such as breast cancer[1].
UNSPSC
12352005
Target
Drug Intermediate
Related Pathways
Others
Field of Research
Cancer
Smiles
CC[C@@H](COC(OCC1=CC=C(B(O)O)C=C1)=O)NC2=NC(NCC(C=C3)=CC=C3C4=CC=CC=N4)=C(N=CN5C(C)C)C5=N2
Molecular Formula
C32H36BN7O5
Molecular Weight
609.48
References & Citations
[1]Zhang N, et al. Self-Assembled Molecular Glue Prodrug System for Enhanced Synergistic Tumor Therapy by Combining CDK12 Protein Degradation and Immunotherapy. ACS Appl Mater Interfaces. 2025 Jul 2;17 (26) :37435-37447.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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