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C199

CAT: 0804-HY-174445Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174445Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
C199 is a PROTAC degrader targeting PRMT4 (DC50 = 106 nM). C199 shows high selectivity for PRMT4 over other protein arginile methyltransferases. C199 exhibits strong cell degradation ability. C199 induces apoptosis in MM cell lines. C199 efficiently clears PRMT4 protein via the VHL-proteasome pathway. C199 has a relatively long half-life and shows strong anti-multiple myeloma (MM) tumor activity (Pink: Target protein ligand ; Blue: E3 ligase ligand (HY-112078), E3 ligase ligand + linker (HY-174474) ; black: Linker).
UNSPSC
12352100
Target
Apoptosis; Histone Methyltransferase; PROTACs
Related Pathways
Apoptosis; Epigenetics; PROTAC
Field of Research
Cancer
Smiles
O=C(N[C@H](C1=CC=C(C=C1)C2=C(N=CS2)C)C)[C@H]3N(C[C@@H](C3)O)C([C@H](C(C)(C)C)NC(CCCCCCCCCCCCCCCC(N4CCC5(CN(C5)C6=NC(C7=CC(OC[C@@H](CNC)O)=CC=C7Cl)=NC(C8=C(ON=C8C)C)=C6C)CC4)=O)=O)=O
Molecular Formula
C67H95ClN10O8S
Molecular Weight
1236.05
References & Citations
[1]Yong Ju, et al. Development of a Selective and Potent PRMT4 PROTAC Degrader with Efficacy against Multiple Myeloma in Vitro and in Vivo. J Med Chem. 2025 Jul 10. 68 (13) : 13973-13989.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PRMT4; von Hippel-Lindau (VHL)

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