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Nsp12-IN-2

CAT: 0804-HY-174439Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174439Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nsp12-IN-2 (Compound 8), the triphosphate metabolite of 4'-thiouridine , is a SARS-CoV-2 Nsp12 inhibitor. Nsp12-IN-2 inhibits the RNA-dependent RNA polymerase (RdRp) activity of the SARS-CoV-2 Nsp12-Nsp7-Nsp8 complex, terminates RNA synthesis and also blocks the RNAylation and NMPylation of Nsp9. Nsp12-IN-2 is promising for research of infections caused by SARS-CoV-2, other coronaviruses, and other RNA viruses[1].
CAS Number
667882-55-5
UNSPSC
12352005
Target
Drug Metabolite; SARS-CoV; Virus Protease
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
O=C(N([C@@H]1S[C@H](COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O)[C@@H](O)[C@H]1O)C=C2)NC2=O
Molecular Formula
C9H12N2Na3O14P3S
Molecular Weight
566.15
References & Citations
[1]Kim M, et al. Identification of 4'-Thiouridine as an Orally Available Antiviral Agent Targeting Both RdRp and NiRAN Functions of SARS-CoV-2 Nsp12. J Med Chem. 2025 Jun 26;68 (12) :12414-12433.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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