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RN277

CAT: 0804-HY-174420Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174420Size:1 Each
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Description
RN277 is an inhibitor for LRRK2 type II kinase. RN277 can be used as a cellular tool targeting the LRRK2 inactive state. RN277 can inhibit LRRK1 kinase activity in vitro. RN277 inhibits LRRK2 kinase activity in vitro (IC50 = 70 nM) . RN277 reduces phosphorylation of Rab8a dose-dependently. RN277 can be studied in research for Parkingson’s disease[1].
UNSPSC
12352005
Target
LRRK2
Related Pathways
Autophagy
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
ClC1=NC(N2CCOCC2)=C(C(C3=CC=CC(NC(NC4=CC(C(C)(C)C)=NN4C5=CC=C(C)C=C5)=O)=C3)=CN6)C6=N1
Molecular Formula
C31H33ClN8O2
Molecular Weight
585.10
References & Citations
[1]Raig ND, et al., (2025) Type-II kinase inhibitors that target Parkinson's Disease-associated LRRK2. bioRxiv [Preprint]. 2025 Feb 13:2024.09.17.613365.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T210823-01RN277

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