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Mefloquine (Standard)

CAT: 0804-HY-17437R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17437R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mefloquine (Standard) is the analytical standard of Mefloquine. This product is intended for research and analytical applications. Mefloquine (Mefloquin), an orally active and potent quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine can be used for malaria, systemic lupus erythematosus and cancer research[1][2][3].
CAS Number
53230-10-7
UNSPSC
12352100
Target
Autophagy; Parasite; Potassium Channel; Reference Standards; ROS Kinase; SARS-CoV
Related Pathways
Anti-infection; Autophagy; Membrane Transporter/Ion Channel; Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Infection; Metabolic Disease; Inflammation/Immunology
Smiles
O[C@H]([C@]1([H])NCCCC1)C2=CC(C(F)(F)F)=NC3=C(C(F)(F)F)C=CC=C32
Molecular Formula
C17H16F6N2O
Molecular Weight
378.31
References & Citations
[1]Kang J, et al. Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK andHERG. J Pharmacol Exp Ther. 2001 Oct;299 (1) :290-6.|[2]Yan KH, et al. Mefloquine exerts anticancer activity in prostate cancer cells via ROS-mediated modulation of Akt, ERK, JNK and AMPK signaling. Oncol Lett. 2013 May;5 (5) :1541-1545.|[3]Kaho Shionoya, et al. Mefloquine, a Potent Anti-severe Acute Respiratory Syndrome-Related Coronavirus 2 (SARS-CoV-2) Drug as an Entry Inhibitor in vitro. Front Microbiol. 2021 Apr 30;12:651403.|[4]Rafael Pacheco-Costa, et al. Reversal of loss of bone mass in old mice treated with mefloquine. Bone. 2018 Sep;114:22-31.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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