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A2073

CAT: 0804-HY-174321Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174321Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A2073 is a flavagline derivative that potently inhibits the proliferation of erythroleukemia cells by causing cell cycle arrest and suppressing the MAPK, NF-κB, and PI3K signaling pathways. A2073 formes stable interactions with cell cycle-related proteins (CDK1, CCNA2, PRIM1) . A2073 exhibits significant anti-proliferative activity against tumor cells while maintaining a favorable toxicity profile in a zebrafish xenograft tumor model. A2073 can be used for the study of acute erythroleukemia[1].
CAS Number
2834742-70-8
UNSPSC
12352005
Target
Akt; NF-κB; p38 MAPK; PI3K
Related Pathways
MAPK/ERK Pathway; NF-κB; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(CN1CCCCC1)O[C@@H]2C[C@@H](C3=CC=CC=C3)[C@@]4(C5=CC=C(OC)C=C5)[C@]2(O)C6=C(OC)C=C(OC)C=C6O4
Molecular Formula
C33H37NO7
Molecular Weight
559.65
References & Citations
[1]Zhou M, et al. A natural flavagline derivative A2073 inhibits the proliferation of erythroleukemia cells by targeting the MAPK, PI3K, NF-κB, and cell cycle pathways. Bioorg Chem. 2025 May 24;163:108612.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
T211237-01A2073

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