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NHE-1-IN-2

CAT: 0804-HY-173517-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-173517-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NHE-1-IN-2 (compound 7g) is a potent NHE-1 inhibitor with an IC50 of 0.78 μM. NHE-1-IN-2 alleviates left ventricular systolic dysfunction in mice model of heart failure[1].
UNSPSC
12352005
Target
Na+/H+ Exchanger (NHE)
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Concentration
10mM
Purity
99.57
Solubility
DMSO : 87.5 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C2=CC=C(Cl)C(C(C3=CC=C(OCC)C=C3)=O)=C2)C=C1)NC(N)=N
Molecular Formula
C23H20ClN3O3
Molecular Weight
421.88
References & Citations
[1]Cao M, et al. Novel sodium-hydrogen exchanger 1 inhibitors with diphenyl ketone scaffold: Design, Synthesis, mechanism and evaluation in mice model of heart failure. Eur J Med Chem. 2025 Jul 5;291:117585.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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