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PDE4D inhibitor 1

CAT: 0804-HY-173290Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173290Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PDE4-IN-1 is a PDE4 inhibitor with high potency (IC50 : 8.6 nM) and selectivity over other PDE subtypes. PDE4-IN-1 inhibits the release of inflammatory cytokines and chemokines. PDE4-IN-1 greatly restores impaired cAMP-CREB signaling pathway. PDE4-IN-1 inhibits proliferation and promotes differentiation to reverse the formation of psoriasis[1].
UNSPSC
12352005
Target
CXCR; Interleukin Related; Phosphodiesterase (PDE) ; TNF Receptor
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
COC([C@H]1C[C@@H](OC2=C3OC(C4=CC=C(OC(F)F)C(OCC5CC5)=C4)=CC3=CC=C2O)CN1)=O
Molecular Formula
C25H25F2NO7
Molecular Weight
489.47
References & Citations
[1]Zhang F, et al. Structure-Based Optimization of Moracin M as Potent and Selective PDE4 Inhibitors with Antipsoriasis Effects. J Med Chem. 2025 Mar 27;68 (6) :6789-6803.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE1; PDE10; PDE2; PDE3; PDE4; PDE5; PDE7; PDE8; PDE9

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