TO-1187 (TFA)

CAT: 0804-HY-173266A-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-173266A-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TO-1187 TFA is a selective HDAC6 PROTAC degrader (DC50: 5.81 nM) . TO-1187 TFA promotes the ubiquitination and degradation of HDAC6 and can be used in the study of hematological malignancies and solid tumors (Pink: HDAC6 ligand (HY-173386) ; Blue: CRBN ligase ligand (HY-41547) ; Black: linker (HY-140212) ) [1].
UNSPSC
12352005
Target
HDAC; PROTACs
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PROTAC
Field of Research
Cancer; Neurological Disease
Purity
98.41
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(C=C1)CN(CC2=CN=CC=C2)CC3=CN(N=N3)CCOCCNC4=CC=CC(C(N5C6CCC(NC6=O)=O)=O)=C4C5=O)NO.OC(C(F)(F)F)=O
Molecular Formula
C36H36F3N9O9
Molecular Weight
795.72
References & Citations
[1]Kollmannsberger C, et al. A Randomized Phase II Study of AGS-16C3F Versus Axitinib in Previously Treated Patients with Metastatic Renal Cell Carcinoma. Oncologist. 2021 Mar;26 (3) :182-e361.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon; HDAC6

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