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GPV0057

CAT: 0804-HY-173162-04Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-173162-04Size:50 mg
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Description
GPV0057 (Compound 5d) is a selective and potent P-glycoprotein (P-gp) inhibitor. GPV0057 is also a selective potassium channel Kir2.1 activator. GPV0057 competitively binds to the substrate-binding site of P-gp, inhibiting ATP-dependent drug efflux to reverse multidrug resistance in tumor cells. GPV0057 can also stabilizes the open state of Kir2.1 and promotes potassium ion influx. GPV0057 is promising for research of tumors with high P-gp expression, Kir2.1-deficient diseases such as heart failure and Andersen-Tawil Syndrome[1][2].
CAS Number
86383-89-3
UNSPSC
12352005
Target
P-glycoprotein; Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer; Cardiovascular Disease
Purity
99.20
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CCC1=CC=CC=C1)C2=C(OCC(CN3CCOCC3)O)C=CC=C2
Molecular Formula
C22H27NO4
Molecular Weight
369.45
References & Citations
[1]Cseke A, et al. Propafenone analogue with additional H-bond acceptor group shows increased inhibitory activity on P-glycoprotein. Arch Pharm (Weinheim) . 2020 Mar;353 (3) :e1900269.|[2]Li E, et al. Development of new Kir2.1 channel openers from propafenone analogues. Br J Pharmacol. 2025 Feb;182 (3) :633-650.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

1-{2-[2-Hydroxy-3-(morpholin-4-yl)propoxy]phenyl}-3-phenylpropan-1-one
CAS Number86383-89-3
PubChem CID10022009
IUPAC Name1-[2-(2-hydroxy-3-morpholin-4-ylpropoxy)phenyl]-3-phenylpropan-1-one
Molecular FormulaC22H27NO4
Molecular Weight369.5
XLogP2.5
Topological Polar Surface Area59
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count9
Heavy Atom Count27
Formal Charge0
Complexity432
SMILES
C1COCCN1CC(COC2=CC=CC=C2C(=O)CCC3=CC=CC=C3)O
InChI
InChI=1S/C22H27NO4/c24-19(16-23-12-14-26-15-13-23)17-27-22-9-5-4-8-20(22)21(25)11-10-18-6-2-1-3-7-18/h1-9,19,24H,10-17H2
InChIKey
POGUJMYEESQTCM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-{2-[2-Hydroxy-3-(morpholin-4-yl)propoxy]phenyl}-3-phenylpropan-1-one
CAS: 86383-89-3
CID: 10022009
Formula: C22H27NO4
MW: 369.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight369.5
XLogP32.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count9
Exact Mass369.19400834
Monoisotopic Mass369.19400834
Topological Polar Surface Area59 Ų
Heavy Atom Count27
Formal Charge0
Complexity432
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T207336-01GPV0057

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