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TWH106

CAT: 0804-HY-173013Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173013Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TWH106 is an inhibitor for Cyclophilin (Cyp) that exhibits good affinity to CypA and CypB with KD of 53 nM and 139 nM. TWH106 inhibits the replication of HIV and HCV, exhibiting antiviral activity[1].
UNSPSC
12352005
Target
Cyclophilin; HCV; HIV
Related Pathways
Anti-infection; Immunology/Inflammation
Field of Research
Infection
Smiles
O=C([C@@H]1CCCN(N1)C([C@@H](NC([C@@H](NC(C/C=C/2)=O)CC3=CC=C(C=C3)[N+]([O-])=O)=O)C)=O)O[C@H](C)C4=CC=C5C=CC2=CC5=N4
Molecular Formula
C32H34N6O7
Molecular Weight
614.65
References & Citations
[1]Newton LS, et al., Macrocycle-based PROTACs selectively degrade cyclophilin A and inhibit HIV-1 and HCV. Nat Commun. 2025 Feb 10;16 (1) :1484.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cyclophilin A; Cyclophilin B

Alternative Products

CatalogName
T206100-01TWH106

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