Insecticidal agent 24

• Description:

  Insecticidal agent 24 is an orally active pyridylspiroindoline frontrunner. Insecticidal agent 24 has antiplasmodial activity (Pf NF54 IC50: 0.08 μM) . Insecticidal agent 24 inhibits hERG activity (IC50: 6.5 μM) . Insecticidal agent 24 reduces parasitemia in a humanized immunodeficient NSG mouse Plasmodium falciparum infection model[1].

• UNSPSC:

  12352005

• Target:

  Parasite

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Smiles:

  COC1=CC2=C(N(C3=CC=NC=C3)CC24CCN(CC4)C)C=C1OCC5=CC=CC=C5

• Molecular Formula:

  C26H29N3O2

• Molecular Weight:

  415.53

• References & Citations:

  [1]Dam J, et al. Cell-Based Progression of Spiroindoline Phenotypic Hits Leads to the Identification of Compounds with Diverging Parasitological Profiles against the Human Malaria Parasite Plasmodium falciparum. J Med Chem. 2025 May 22;68 (10) :10156-10172.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported