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SP11

CAT: 0804-HY-172942-04Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-172942-04Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SP11 is a mitochondrial reactive oxygen species (ROS) inhibitor. SP11 activates Fis1 by binding to Cys41 (IC50: 9.4 µM) and increases the translocation of Drp1 to mitochondria. SP11 can be used in studies on the protection against oxidative stress damage[1].
CAS Number
2629218-24-0
UNSPSC
12352005
Target
Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease
Purity
98.91
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
CN(C(CCl)=O)CCCN1C2=CC=CC=C2SC3=C1C=CC=C3
Molecular Formula
C18H19ClN2OS
Molecular Weight
346.87
References & Citations
[1]Pokhrel S, et al. A hidden cysteine in Fis1 targeted to prevent excessive mitochondrial fission and dysfunction under oxidative stress. Nat Commun. 2025 May 6;16 (1) :4187.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

2-chloro-N-methyl-N-(3-phenothiazin-10-ylpropyl)acetamide
CAS Number2629218-24-0
PubChem CID154871094
IUPAC Name2-chloro-N-methyl-N-(3-phenothiazin-10-ylpropyl)acetamide
Molecular FormulaC18H19ClN2OS
Molecular Weight346.9
XLogP4.6
Topological Polar Surface Area48.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Heavy Atom Count23
Formal Charge0
Complexity386
SMILES
CN(CCCN1C2=CC=CC=C2SC3=CC=CC=C31)C(=O)CCl
InChI
InChI=1S/C18H19ClN2OS/c1-20(18(22)13-19)11-6-12-21-14-7-2-4-9-16(14)23-17-10-5-3-8-15(17)21/h2-5,7-10H,6,11-13H2,1H3
InChIKey
DGIQIBHRQRNGPY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-chloro-N-methyl-N-(3-phenothiazin-10-ylpropyl)acetamide
CAS: 2629218-24-0
CID: 154871094
Formula: C18H19ClN2OS
MW: 346.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight346.9
XLogP34.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass346.0906621
Monoisotopic Mass346.0906621
Topological Polar Surface Area48.9 Ų
Heavy Atom Count23
Formal Charge0
Complexity386
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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