MC4762

CAT: 0804-HY-172451Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-172451Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

MC4762 is an inhibitor of NOX2 and MAOB, with IC50 values of 0.155 μM and 0.182 μM, respectively. MC4762 has anti-inflammatory activity, can inhibit the production of ROS, and downregulate the expression of pro-inflammatory cytokines iNOS, IL-1β, and IL-6[1].

UNSPSC

12352005

Target

Interleukin Related; Monoamine Oxidase; NADPH Oxidase; NO Synthase; Reactive Oxygen Species (ROS)

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

Field of Research

Inflammation/Immunology

Smiles

C#CCN(CC1=CC=C(CN2N=NC3=C(SC4=NC5=CC=CC=C5O4)N=CN=C32)C=C1)C

Molecular Formula

C23H19N7OS

Molecular Weight

441.51

References & Citations

[1]Noce B, et al. Design of Benzyl-triazolopyrimidine-Based NADPH Oxidase Inhibitors Leads to the Discovery of a Potent Dual Covalent NOX2/MAOB Inhibitor. J Med Chem. 2025 Mar 5.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MAO-B; NOX2

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