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H1L1A1B3

CAT: 0804-HY-172332Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172332Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
H1L1A1B3 is an ionizable cationic lipid used in the formation of lipid nanoparticles (LNPs) for the delivery of circular RNA (circRNA). H1L1A1B3-LNPs demonstrates a fourfold increase in circRNA transfection efficiency in lung cancer cells over ALC-0315. H1L1A1B3 can activate the NF-κB/IRF immune pathways[1].
CAS Number
3097638-09-7
UNSPSC
12352211
Target
Liposome; NF-κB
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(NC1CCCCC1)C(N(C(CCC(CCCCC)C)=O)CCCN(C)C)CCCCCOC(CCCCCCCCCCC)=O
Molecular Formula
C40H77N3O4
Molecular Weight
664.06
References & Citations
[1]Xu S, et al. Tumor-Tailored Ionizable Lipid Nanoparticles Facilitate IL-12 Circular RNA Delivery for Enhanced Lung Cancer Immunotherapy. Adv Mater. 2024 Jul;36 (29) :e2400307.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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T203795-01H1L1A1B3

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