Tosposertib

CAT: 0804-HY-172240-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-172240-01Size:5 mg

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Description

Tosposertib is an ALK5/VEGFR2 dual inhibitor (IC50 = 1.2 nM/4.9 nM) . Tosposertib directly restores the activity of damaged cytotoxic T lymphocytes (CTLs) and natural killer cells inhibited by TGFβ and suppresses the activity and viability of regulatory T cells. Tosposertib can be used for the study of melanoma and colon cancer[1].

CAS Number

1418305-55-1

Product Name Alternative

TU2218 (free base)

UNSPSC

12352005

Target

Anaplastic lymphoma kinase (ALK) ; VEGFR

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Purity

99.81

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=CC=CC(C(NC2=NCCN23)=C3C4=CN5N=CN=C5C=C4)=N1

Molecular Formula

C17H15N7

Molecular Weight

317.35

References & Citations

[1]Lee JY, et al., 2-pyridyl substituted imidazoles as alk5 and/or alk4 inhibitors. WO2013009140|[2]Kim NH, et al. ALK5/VEGFR2 dual inhibitor Tosposertib alone or in combination with immune checkpoint inhibitors enhances immune-mediated antitumor effects. Cancer Immunol Immunother. 2024 Aug 6;73 (10) :190.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

VEGFR2/KDR/Flk-1

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