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BG11

CAT: 0804-HY-172092Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172092Size:1 Each
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Description
BG11 induces the accumulation of Fe2+ and intracellular lipid peroxides, induces ferroptosis. BG11 regulates the expression of Bax and Bcl-2 proteins, and induces apoptosis in MDA-MB-231 cell. BG11 arrests the cell cycle at G0/G1 and S phase, inhibits the proliferation of TNBC cancer cell (IC50 for MDA-MB-231 and BT549 is 0.49 μM and 0.52 μM), and inhibits the cell migration and invasion. BG11 exhibits antitumor efficacy in mouse models[1].
CAS Number
3065877-52-0
UNSPSC
12352005
Target
Apoptosis; Ferroptosis
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC1=C(C)SC2=C1C(C3=CC=C(C=C3)Cl)=N[C@H](C4=NN=C(N42)C)CC(NC5CCN(CC5)C(CCl)=O)=O
Molecular Formula
C26H28Cl2N6O2S
Molecular Weight
559.51
References & Citations
[1]Ding R, et al., Discovery of novel JQ1 derivatives as dual ferroptosis and apoptosis inducers for the treatment of triple-negative breast cancer. Eur J Med Chem. 2025 Jan 11;286:117275.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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