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RS47

CAT: 0804-HY-171579-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-171579-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RS47 (Compound 1a) is a selective inhibitor of the non-canonical NF-κB signaling pathway targeting RelB with a Kd of 1.1 μM. RS47 competitively blocks RelB binding to target DNA, inhibiting downstream gene (e.g., BCL3, PIM2) expression, thereby suppressing tumor cell proliferation. RS47 is promising for research of cancers with aberrant activation of the non-canonical NF-κB pathway, such as colorectal cancer and B lymphoma[1][2].
CAS Number
301655-16-3
UNSPSC
12352005
Target
NF-κB
Related Pathways
NF-κB
Field of Research
Cancer
Purity
98.0
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
OC1=CC=C(C(/C(C)=N/NC2=C3C(CCCC4)=C4SC3=NC=N2)=C1)O
Molecular Formula
C18H18N4O2S
Molecular Weight
354.43
References & Citations
[1]Li C, et al. Development of RelB-targeting small-molecule inhibitors of non-canonical NF-κB signaling with antitumor efficacy. Mol Ther. 2025 Apr 2;33 (4) :1519-1534.|[2]Bassetto M, et al. Computer-aided identification, synthesis and evaluation of substituted thienopyrimidines as novel inhibitors of HCV replication. Eur J Med Chem. 2016 Nov 10;123:31-47.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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