GSM III

• Description:

  GSM III is a γ-Secretase complexe (GSEC) modulator. GSM III significantly regulates amyloid-β (Aβ) length at the extracellular interface between the protease (NCT, PSEN) and the substrate APPC99. GSM III can be used for Alzheimer's disease (AD) research[1].

• UNSPSC:

  12352005

• Target:

  Amyloid-β; γ-secretase

• Related Pathways:

  Neuronal Signaling; Stem Cell/Wnt

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Purity:

  99.67

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1C (N2C[C@@H] (C) N1CC3=CN (C) C4=C3C=C (C (F) (F) F) C=C4) =CC=C (N5C=C (C) N=C5) C2=O

• Molecular Formula:

  C24H22F3N5O2

• Molecular Weight:

  469.46

• References & Citations:

  [1]Petit D, et al. Extracellular interface between APP and Nicastrin regulates Aβ length and response to γ-secretase modulators. EMBO J. 2019 Jun 17;38 (12) :e101494.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1493797-28-6