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SMARt751

CAT: 0804-HY-171317-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-171317-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SMARt751 targets the transcriptional regulatory factor VirS, inhibits its DNA binding ability, upregulates the mymA operon expression, thereby activating Ethionamide , enhancing the antimicrobial activity of Ethionamide. SMARt751 enhances the antibacterial activity of Ethionamide against M. tuberculosis, reverses the Ethionamide resistance. SMARt751 improves the antibacterial effect of Ethionamide and reduces its effective dose in mouse models. SMARt751 can cross blood brain barrier[1].
CAS Number
1616370-52-5
UNSPSC
12352005
Target
Bacterial
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Purity
99.99
Smiles
O=C(CCC(F)(F)F)N1CCC(CC1)C2=CC=C(C=C2)F
Molecular Formula
C15H17F4NO
Molecular Weight
303.30
References & Citations
[1]Flipo M, et al., The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis. Sci Transl Med. 2022 May 4;14 (643) :eaaz6280.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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