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EAPB0503

CAT: 0804-HY-171184Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-171184Size:1 Each
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Description
EAPB0503 is a quinoline compound with anti-tumor activity, showing strong cytotoxicity against melanoma cells in vitro (IC50=200 nM) . EAPB0503 can induce specific cell cycle arrest in mitosis of CML cells and directly activate apoptosis, leading to an increase in the G0 cell population, disruption of mitochondrial membrane potential, PARP cleavage, and DNA fragmentation. EAPB0503 also reduces the levels of BCR-ABL protein [1] [2].
CAS Number
1140627-77-5
UNSPSC
12352005
Target
Apoptosis; Bcr-Abl; Mitosis; PARP
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
COC1=CC(C2=CN=C3N2C4=C(C=CC=C4)N=C3NC)=CC=C1
Molecular Formula
C18H16N4O
Molecular Weight
304.35
References & Citations
[1]Sonia Khier, et al. Quantitation of imidazo[1,2-a]quinoxaline derivatives in human and rat plasma using LC/ESI-MS. J. Sep. Sci. 2009, 32, 1363-1373.|[2]Jessica Saliba, et al. EAPB0503, a novel imidazoquinoxaline derivative, inhibits growth and induces apoptosis in chronic myeloid leukemia cells. Anticancer Drugs. 2014 Jul;25 (6) :624-32.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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