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DK2403

CAT: 0804-HY-171178-04Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-171178-04Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DK2403 (compound 25) is a MAP2K7 inhibitor (IC50= 0.01 μM) . DK2403 can effectively inhibit MAP2K7 without significantly disrupting the larger kinase group and can be used to study childhood T-cell acute lymphoblastic leukemia[1].
CAS Number
2902651-64-1
UNSPSC
12352005
Target
P38 MAPK
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
98.24
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(CCl)NC1=CC(OC2=NC=NC(NCC3=CC=CC=C3)=C2)=CC=C1
Molecular Formula
C19H17ClN4O2
Molecular Weight
368.82
References & Citations
[1]Kim DR, et al. Rational Design of Highly Potent and Selective Covalent MAP2K7 Inhibitors. ACS Med Chem Lett. 2023 Apr 17;14 (5) :606-613.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

MAP2K7 inhibitor DK2403
CAS Number2902651-64-1
PubChem CID171346385
IUPAC NameN-[3-[6-(benzylamino)pyrimidin-4-yl]oxyphenyl]-2-chloroacetamide
Molecular FormulaC19H17ClN4O2
Molecular Weight368.8
XLogP3.7
Topological Polar Surface Area76.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Heavy Atom Count26
Formal Charge0
Complexity434
SMILES
C1=CC=C(C=C1)CNC2=CC(=NC=N2)OC3=CC=CC(=C3)NC(=O)CCl
InChI
InChI=1S/C19H17ClN4O2/c20-11-18(25)24-15-7-4-8-16(9-15)26-19-10-17(22-13-23-19)21-12-14-5-2-1-3-6-14/h1-10,13H,11-12H2,(H,24,25)(H,21,22,23)
InChIKey
SWAPCFYOLJWGBA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of MAP2K7 inhibitor DK2403
CAS: 2902651-64-1
CID: 171346385
Formula: C19H17ClN4O2
MW: 368.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight368.8
XLogP33.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass368.1040035
Monoisotopic Mass368.1040035
Topological Polar Surface Area76.1 Ų
Heavy Atom Count26
Formal Charge0
Complexity434
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T202320-01DK2403

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