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Clonixeril

CAT: 0804-HY-171012Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-171012Size:1 Each
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Description
Clonixeril (NSC 335504) is a non-nucleotide hSTING modulator. Clonixeril has weak agonist activity at micromolar concentrations and results in antagonism of the hSTINGWT pathway at low femtomolar (10-15 M) and in some cases even attomolar (10-18 M) concentrations. Clonixeril reduces hSTING oligomerization at a concentration of 1 aM-1 pM[1].
CAS Number
21829-22-1
Product Name Alternative
NSC 335504
UNSPSC
12352005
Target
STING
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=CC=CN=C1NC2=C(C)C(Cl)=CC=C2)OCC(CO)O
Molecular Formula
C16H17ClN2O4
Molecular Weight
336.77
References & Citations
[1]Robert P. Sparks, et al. Discovery of Clonixeril as a Sub-Femtomolar Modulator of the Human STING Receptor. ACS Central Science Article ASAP
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
GTR19263408-01Clonixeril

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