Antimicrobial agent-39

• Description:

  Antimicrobial agent-39 (Compound 8i) is an antibiotic that targets 50S ribosomal subunit and inhibits bacterial protein synthesis. Antimicrobial agent-39 disrupts bacterial cell membranes, leads to leakage of cell contents, thereby exhibiting board-spectrum actibacterial activity. Antimicrobial agent-39 targets organic cation transporters (OCTs), accumulates in infected kidneys, thereby ameliorating pyelonephritis in mouse models[1].

• UNSPSC:

  12352005

• Target:

  Antibiotic; Bacterial

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection; Inflammation/Immunology

• Smiles:

  O=C1[C@]2([H])[C@@]([C@@H](C)[C@H](O)[C@@](C=C)(C)C[C@@H](OC(CSC3=NC(C=C[N+](CC4=CC=C(C)C=C4)=C5)=C5N3)=O)[C@@]26C)(CC[C@H]6C)CC1.[Br-]

• Molecular Formula:

  C36H46BrN3O4S

• Molecular Weight:

  696.74

• References & Citations:

  [1]Tian L, et al., Kidney Targeting Smart Antibiotic Discovery: Multimechanism Pleuromutilins for Pyelonephritis Therapy. J Med Chem. 2025 Feb 13;68 (3) :3335-3355.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported