Antidepressant agent 8

• Description :

  Antidepressant agent 8 (Compound 1f) is a selective antagonist for the NMDA receptor GluN1/2A with an IC50 of 2.94 μmol/L. Antidepressant agent 8 exhibits antidepressant-like effects in Hydrocortisone (HY-N0583) -induced zebrafish depression model. Antidepressant agent 8 can cross blood-brain barrier[1].

• UNSPSC :

  12352005

• Target :

  IGluR

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Smiles :

  FC1=CC(CNC2=NN=C(SCC(NCC3CCCCC3)=O)S2)=CC=C1

• Molecular Formula :

  C18H23FN4OS2

• Molecular Weight :

  394.53

• References & Citations :

  [1]Zhao F, et al., Discovery of Brain-Penetrative Negative Allosteric Modulators of NMDA Receptors Using FEP-Guided Structure Optimization and Membrane Permeability Prediction. J Chem Inf Model. 2025 Jan 27;65 (2) :857-872.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  NMDA Receptor

• CAS Number :

  [3066104-04-6]