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Antidepressant agent 8

CAT: 0804-HY-170898Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170898Size:1 Each
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Description
Antidepressant agent 8 (Compound 1f) is a selective antagonist for the NMDA receptor GluN1/2A with an IC50 of 2.94 μmol/L. Antidepressant agent 8 exhibits antidepressant-like effects in Hydrocortisone -induced zebrafish depression model. Antidepressant agent 8 can cross blood-brain barrier[1].
CAS Number
3066104-04-6
UNSPSC
12352005
Target
IGluR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
FC1=CC(CNC2=NN=C(SCC(NCC3CCCCC3)=O)S2)=CC=C1
Molecular Formula
C18H23FN4OS2
Molecular Weight
394.53
References & Citations
[1]Zhao F, et al., Discovery of Brain-Penetrative Negative Allosteric Modulators of NMDA Receptors Using FEP-Guided Structure Optimization and Membrane Permeability Prediction. J Chem Inf Model. 2025 Jan 27;65 (2) :857-872.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NMDA Receptor

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