Antidepressant agent 8

• Description:

  Antidepressant agent 8 (Compound 1f) is a selective antagonist for the NMDA receptor GluN1/2A with an IC50 of 2.94 μmol/L. Antidepressant agent 8 exhibits antidepressant-like effects in Hydrocortisone (HY-N0583) -induced zebrafish depression model. Antidepressant agent 8 can cross blood-brain barrier[1].

• UNSPSC:

  12352005

• Target:

  IGluR

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Smiles:

  FC1=CC(CNC2=NN=C(SCC(NCC3CCCCC3)=O)S2)=CC=C1

• Molecular Formula:

  C18H23FN4OS2

• Molecular Weight:

  394.53

• References & Citations:

  [1]Zhao F, et al., Discovery of Brain-Penetrative Negative Allosteric Modulators of NMDA Receptors Using FEP-Guided Structure Optimization and Membrane Permeability Prediction. J Chem Inf Model. 2025 Jan 27;65 (2) :857-872.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  NMDA Receptor

• CAS Number:

  [3066104-04-6]