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JD123

CAT: 0804-HY-170879-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-170879-01Size:1 mg
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Description
JD123 inhibits JNK1 activity and the expression of cJun (1-135) . JD123 is a ATP-competitive p38-γ MAPK inhibitor, but not effect to ERK1, ERK2, or p38-α, p38-β or p38-δ.[1].
CAS Number
696629-98-8
UNSPSC
12352005
Target
JNK; p38 MAPK
Related Pathways
MAPK/ERK Pathway
Field of Research
Cancer
Purity
90.0
Smiles
CC1=C(SC(N)=N1)C2=CSC(NC3=CC=CN=C3)=N2
Molecular Formula
C12H11N5S2
Molecular Weight
289.38
References & Citations
[1]Ngoei KR, et al. Identification and characterization of bi-thiazole-2,2'-diamines as kinase inhibitory scaffolds. Biochim Biophys Acta. 2013;1834 (6) :1077-1088.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

Chemical Information

4'-Methyl-N*2*-pyridin-3-yl-[4,5']bithiazolyl-2,2'-diamine
CAS Number696629-98-8
PubChem CID972473
IUPAC Name4-methyl-5-[2-(pyridin-3-ylamino)-1,3-thiazol-4-yl]-1,3-thiazol-2-amine
Molecular FormulaC12H11N5S2
Molecular Weight289.4
XLogP2.5
Topological Polar Surface Area133
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Heavy Atom Count19
Formal Charge0
Complexity306
SMILES
CC1=C(SC(=N1)N)C2=CSC(=N2)NC3=CN=CC=C3
InChI
InChI=1S/C12H11N5S2/c1-7-10(19-11(13)15-7)9-6-18-12(17-9)16-8-3-2-4-14-5-8/h2-6H,1H3,(H2,13,15)(H,16,17)
InChIKey
TXTUDXNTPIORFT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4'-Methyl-N*2*-pyridin-3-yl-[4,5']bithiazolyl-2,2'-diamine
CAS: 696629-98-8
CID: 972473
Formula: C12H11N5S2
MW: 289.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight289.4
XLogP32.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass289.04558772
Monoisotopic Mass289.04558772
Topological Polar Surface Area133 Ų
Heavy Atom Count19
Formal Charge0
Complexity306
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19249799-01JD123

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