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TDK-HCPT

CAT: 0804-HY-170842Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170842Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TDK-HCPT is a small-molecule conjugate that links glutathione-sensitive thiamine disulfide to the chemotherapy drug 10-Hydroxycamptothecin via a thioketal bond. TDK-HCPT can target tumor cells and prolong the retention of chemotherapy agents within tumor cells. TDK-HCPT can inhibit tumor growth, induce apoptosis of tumor cells, and has anti-tumor activity[1].
UNSPSC
12352005
Target
Apoptosis
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
CC(CSS/C(CCOC(CCCSC(C)(C)SCCCC(OC1=CC=C(N=C(C(N2C3)=CC([C@@](O)(CC)C(OC4)=O)=C4C2=O)C3=C5)C5=C1)=O)=O)=C(C)\N(C)C=O)C
Molecular Formula
C42H53N3O9S4
Molecular Weight
872.14
References & Citations
[1]Yang C, et al. An oxidation-reduction-triggered thiamine disulfide-based prodrug of 10-hydroxycamptothecin for selective tumor cell locking and therapeutic delivery. Eur J Med Chem. 2025 Feb 15;284:117233.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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