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DQ661

CAT: 0804-HY-170670Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170670Size:1 Each
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Description
DQ661 is a potent PPT1 inhibitor. DQ661 is a dimeric quinacrine autophagy inhibitor. DQ661 inhibits mTORC1 activity. DQ661 decreases the protein expression of pS6K T389, pS6 S240-244. DQ661 shows anticancer activity[1][2].
CAS Number
2027551-01-3
UNSPSC
12352005
Target
Autophagy; mTOR
Related Pathways
Autophagy; PI3K/Akt/mTOR
Field of Research
Cancer
Smiles
ClC(C=CC1=C2NCCCCCCN(CCCCCCNC3=C4C=CC(Cl)=CC4=NC5=C3C=C(OC)C=C5)C)=CC1=NC6=C2C=C(OC)C=C6
Molecular Formula
C41H47Cl2N5O2
Molecular Weight
712.75
References & Citations
[1]Nicastri MC, et al. Dimeric quinacrines as chemical tools to identify PPT1, a new regulator of autophagy in cancer cells. Mol Cell Oncol. 2017 Nov 30;5 (1) :e1395504.|[2]Rebecca VW, et al. A Unified Approach to Targeting the Lysosome's Degradative and Growth Signaling Roles. Cancer Discov. 2017 Nov;7 (11) :1266-1283.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
T204315-01DQ661

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