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2DII

CAT: 0804-HY-169960-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-169960-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
2DII is a potent and selective mTORC2 inhibitor. 2DII selectively binds mSin1 PH domain and decreases the expression of AKT1 phosphorylation[1].
UNSPSC
12352005
Target
MTOR
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
98.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C([C@H]1N(C(C2=CC=C(OC)C(S(=O)(NCC3=CC=C(Cl)C=C3)=O)=C2)=O)CCC1)N[C@H](C(NCCOCCOCC(N[C@H](C(N)=O)CNC(CCCCCCC/C=C\CCCCCC)=O)=O)=O)CC4=CC=CC=C4
Molecular Formula
C54H76ClN7O11S
Molecular Weight
1066.74
References & Citations
[1]Gonse A, et al. Small Molecule Modulator of the mTORC2 Pathway Discovered from a DEL Library Designed to Bind to Pleckstrin Homology Domains. ACS Chem Biol. 2024 Dec 20;19 (12) :2502-2514.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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