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CJZ3

CAT: 0804-HY-169782Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169782Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CJZ3 is an reversible inhibitor for P-glycoprotein (P-gp), that accumulates the drug (Rh123) in cells, and improve the permeability of the blood-brain barrier (BBB) [1].
CAS Number
766508-73-0
UNSPSC
12352005
Target
P-glycoprotein
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Neurological Disease
Smiles
FC1=CC=C(C(N2CCN(CC2)CC3=CC=C(C(Cl)=C3)Cl)C4=CC=C(C=C4)F)C=C1
Molecular Formula
C24H22Cl2F2N2
Molecular Weight
447.35
References & Citations
[1]Ji BS, et al., CJZ3, a lomerizine derivative, modulates P-glycoprotein function in rat brain microvessel endothelial cells. Acta Pharmacol Sin. 2006 Apr;27 (4) :414-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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