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PTX80

CAT: 0804-HY-169779-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-169779-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PTX80 is an antagonist of p62 with an IC50 value of 31.18 nM. PTX80 reduces tumor volume in an HCT116 colorectal cancer mouse xenograft model[1].
CAS Number
2376297-69-5
UNSPSC
12352005
Target
P62
Related Pathways
Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.5700
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(/C(CN(C/1)S(CCCN(C)C)(=O)=O)=C/C2=CC=C(C=C2)C#N)C1=C\C3=CC=C(C=C3)C#N
Molecular Formula
C26H26N4O3S
Molecular Weight
474.57
References & Citations
[1]Ori Kalid, et al. PTX80, a novel compound targeting the autophagy receptor p62/SQSTM1 for treatment of cancer. Chem Biol Drug Des. 2022 Nov;100 (5) :623-638.|[2]Ori Kalid, et al. PTX80, a novel compound targeting the autophagy receptor p62/SQSTM1 for treatment of cancer. Chem Biol Drug Des. 2022 Nov;100 (5) :623-638.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
T203052-01PTX80

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