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GK420

CAT: 0804-HY-168431Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168431Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GK420 (AVX420) is a potent inhibitor of cytosolic phospholipase A2α (cPLA2α), with the XI (50) of 0.0016. GK420 inhibits arachidonic acid release with the EC50 of 0.09 μM. GK420 plays an important role in cancer research[1].
CAS Number
1621517-60-9
Product Name Alternative
AVX420
UNSPSC
12352005
Target
Phospholipase
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C1=NC(C(OC)=O)=CS1)COC2=CC=C(OCCCCCCC)C=C2
Molecular Formula
C20H25NO5S
Molecular Weight
391.48
References & Citations
[1]Felicity J Ashcroft, et al. Next generation thiazolyl ketone inhibitors of cytosolic phospholipase A2 α for targeted cancer therapy. Nat Commun. 2025 Jan 2;16 (1) :164.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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