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M04

CAT: 0804-HY-168384Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168384Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
M04 is an agonist of STING. It induces the expression of the IFN reporter gene in HEK293T cells expressing wild-type human STING, but does not induce this expression in HEK293T cells expressing the R71H-G230A-R293Q (HAQ) STING variant or in mouse RAW 264.7 cells, indicating that its activity is dependent on allelic and species variations. M04 induces the production of TNF-α, IL-10, IL-1β, and IL-12p70 in human peripheral blood mononuclear cells (PBMCs) . At a concentration of 50 µM, M04 stimulates dendritic cells isolated from PBMCs to express the MHC class II cell surface receptor HLA-DR and co-stimulatory molecules CD40, CD80, and CD86, and also enhances their ability to activate T cells in an ex vivo assay. M04 can be used in research on inflammatory immune diseases[1].
CAS Number
875158-73-9
UNSPSC
12352005
Target
CD28; Interleukin Related; STING; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
O=S(C1=CC=C(C)C=C1)(C2=C(N(C)C)SC(S(=O)(C3CCCCC3)=O)=N2)=O
Molecular Formula
C18H24N2O4S3
Molecular Weight
428.59
References & Citations
[1]Abraham J, et al. Characterization of a Novel Compound That Stimulates STING-Mediated Innate Immune Activity in an Allele-Specific Manner. Front Immunol. 2020 Jul 8;11:1430.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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